vicissitudes

noun
  1. 1

    Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.

    syn:ups and downs
  2. 2

    (often in the plural) A change, especially in one's life or fortunes.

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Source: https://en.wiktionary.org/wiki/vicissitude, https://en.wiktionary.org/wiki/vicissitudes

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