gender dysphoria

/JH EH1 N D ER0 D IH0 S F AO0 R IY0 AH0/
noun
  1. 1

    A profound and persistent unhappiness related to characteristics associated with one's birth-assigned sex, experienced by some transgender people. Opposite of gender euphoria.

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Source: https://en.wiktionary.org/wiki/gender%20dysphoria